We are actively recruiting new colleagues to join our team, including postdoctoral fellows, graduate students, and research assistants. We aim to build an intellectually stimulating and collaborative environment. Lab members will work to explore the interface of gene regulation and condensate biology with many opportunities to learn and build upon the latest methods in chromatin, epigenomics, transcription, and condensate research.
The primary goal of the Sabari Lab is to understand how the machinery required for gene activation is organized within the nucleus in healthy and diseased cell states. The process of gene activation requires hundreds of unique proteins and RNAs that must engage with specific DNA elements to position RNA Polymerase at a gene for transcription. We study the role of dynamic compartments called biomolecular condensates in organizing the transcriptional machinery. We investigate how nuclear condensates form at specific genomic loci, how they function to compartmentalize biochemistry, and how they are dynamically regulated. The lab focuses on the roles of protein disorder, regulatory DNA element clustering, and active processes in the formation and function of nuclear condensates. We investigate these processes in various biological contexts including adipogenesis, stem cell differentiation, and cancer. We employ an array of tools including live cell microscopy, in vitro biochemistry, proteomics and epigenomics.
Please email your CV, statement of interests, and contact information for three references to email@example.com
We are excited to have graduate students in the lab.
If you are interested in rotating, please email Ben to schedule a meeting.